The only problem I see it the vanity in front of the window. You'll need a mirror there. Have you made yourself a list of must-haves? That will help narrow down your design.

Here are two versions I had worked on a bit last night and this morning.

Houseful-thank you. We both like the general layout(s) We need to play with it a bit but believe its 90%. Our thoughts are we will drop the little sitting area and either add another cabinet to the end of the sinks or enlarge the sink counter and install a wall cabinet between the sinks. Unfortunately we cannot add another window in the WC.

what s/w program are you using?

We are meeting with a custom cabinet builder this a.m. for the kitchen. The box cabinets were not giving us all the flexibility we wanted and we are interested to see if we can get everything we are looking for at a price that is close. We will add this to his list

Glad you're getting close. I do think you should pick your tub right away if you haven't already.

I use Punchpro, the same as you. Usually I hit "print screen" and copy the floorplan into the Paint program. However, my Paint locks up which forces me to print the floorplan and scan back into the computer. So now, I choose the "export 3D" from the Punch file menu and post the 3D overhead. If you need further instructions to do that, let me know.

I strongly urge you to put some kind of seating in the bathroom. It's nice to have a place to sit for putting on shoes, clipping or painting toenails, etc. I think it would be expected in a bathroom this size. Just for fun, here is an idea for a corner tub with a padded window seat.
The vanity in this one is 9.5' long.

Decisions, decisions! It is hard isn't it!
I'd shy away from the vanity under the window.
I'm a huge fan of pocket doors and you have quite a few places where you could easily put them and so maximize your space.
I like having the closet separate from the bathroom. If you had the closet entrance in the bedroom you could have a long vanity.

LOL, the kitchen was easier than this! The good news is we met with a custom cabinet builder yesterday that appears to have all the answers plus and we will be using him (for the kitchen). He looked at the designs from our KD and said here is where you will have problems - and he was right. He said he sees them all the time from designers who do not do the actual installation experience or had scars he has from 30-40 years of experience. Better yet, his pricing was in line with what we were receiving for the custom/semicustom cabinets. We have used him before for a vanity and it was perfect. Wish we had started there. Anyway, WRT to the bath:

Houseful, thanks again. I will have to give your way a try. When I do not use the software for a while, its tough for me to remember all the functions and its less then intuitive. One of our biggest objectives is to keep the size of the closet as big as possible. What if I put a sitting place in there vs in front of the window? Neither place would have a mirror. We are heading down to Expo to look at tubs and kitchen faucets/sinks later this a.m.

Gbsim, we also like pocket doors - secret to them is good hardware I think. I see one going into the WC at a minimum

One thing that helps with layout is to nail down the dimensions of the components that you require. You show a 4'x5' shower. Do you require one that large? You could go with 3'x5' or 3.5'x5'. In your original layout you show getting out of the shower right at a vanity. that might be a little odd if 2 people try to use the bathroom.
What size tub are you showing?
Have you tried putting the toilet room where you have the bathroom shelving and the odd corner in the closet? This would free up space on the outside wall for a vanity and makeup area in front of the window.