Agree with Floral_uk, it looks like one of the black nightshades, probably S. douglasii given your location. There are several very similar species, and they grow wild pretty much everywhere. I take great pains to ensure that they never go to seed in my gardens, and they still crop up from dormant seed or from bird droppings. When I lived in San Diego, the local Hmong community cultivated one of the black nightshades extensively. There is a pretty god write up of the various species & their properties in the link below. Personally, I would just treat it like the weed that it is & dispose of it. Really nice jade plant bush behind it, by the way. Here is a link that might be useful: Black nightshade

It's not native, and it's spreading into southeastern forests. The Piedmont has already been damaged enough. https://davesgarden.com/guides/articles/view/2097

Realistically, you have two choices with a well grown invasive plant like this bittersweet. One is to cut to the ground all vines and on the fresh cuts paint a brush killer. Yes, it uses herbicide, but in smaller, very targeted use. This might take one repetition, but I haven’t had times when even a well established invasive takes more than one repetition. Otherwise, cut all the stems, and as soon as it resprouts, remove them before they are fully leafed out, and then repeat for the next two or more growing seasons every week or so. The goal here is to prevent it ever regrowing enough leaves to create energy so that the plant uses up all its reserves and is unable to replace them. With bittersweet, new stems won’t just grow from the main stem area, but will sprout from roots as well. If you let it establish leaves, it will start replacing the energy it used up trying to regrow, so this will take persistence and consistency. When a plant is really large and inter-grown with other plants like this, you won’t be able to remove all the roots with anything less than a tractor or bulldozer.

Thank you. I was worried that it is the dreaded chameleon plant that I’ve seen Discussed in other threads. So now I have crazy ivy AND this chameleon plant vying for the same spot. It’s a mess. I saw a few last year but I didn’t know any better and I thought the flowers looked nice. Then this spring I found this forum and started seeing mention of the chameleon. I thought it looked familiar..... ahhh I have too many invasives already