Zep516, Thanks for the link to Dells support for laptop that he has. I have download the driver for him and will transfer it to his computer via a thumb drive. He can then keep it as a back up file in case the problem surfaces again.

Is it a laptop or a desktop computer? If it is a laptop and you have not disabled the touchpad, it can cause the cursor to move around if one of your hands brushes the pad.

I have 2 wireless mouses or um mice?? that I really like one is a GE and one is a Gear Head MP2000WU both are the smaller size notebook mouse which I much prefer they just fit and feel better in my hand than the big ones. The Gear Head has the suede feel rubber on the click part of the top and on the sides where you grip it. They both have the small usb receiver that is about the size of a thumb drive or smaller. The GE has a place that opens on the top that the receiver stores in which is nice. One takes AAA one takes AA batteries. I have tried wireless keyboards and no matter the brand I just did not like them, they go through batteries like crazy even the rechargables. GEAR HEAD MP2000WU Mine is all black but it is this one. the dongle for this one is a bit wide and in some cases can partly block the usb port beside it but it does come with a cord to use as an extension if you need it. GE 98792 that is what the GE one looks like, I use it daily it is my main mouse and I love it, nice and small easy to hold batteries last quite well and you can put the dongle inside under the black center part. I have had it and use it daily for a couple years I think, it has never had any problems. oh I just found my mouse in pink, for an excellent price too , it is usually listed around $30 ... I may need this pink one LOL Pink but I see it also comes in blue, mine is silver and black. I had bought a set with a logitech wireless keyboard and mouse but brought it back after a few days, it ate batteries and the keyboard had keys doing kkkkkksssssssss ooooooo etc all the time, Hated it. This one is also a great mouse my husband has it, it comes in handy since he does a lot of conferences and can use the built in laser pointer. It last forever on batteries. Has extra long range. GE 98505 Wireless Mini Presenter Mouse

Well, it is not the toggling fn+f5, it has nothing to do with a wireless mouse. I have run my AV, checked to see if there was a conflict with any other program, there is not. Wen I start up regularly my mouse will not work, I can move the mouse around on the screen, but as far as clicking on anything, I can't. My laptop is a Toshiba L655D, I have not downloaded anything new prior to the mouse not working. I did d/l a driver for the touchpad from Toshiba's support site. The keyboard mouse/touchpad only works in SAFE MODE. And, I had a wireless mouse, I had changed the battery, checked for drivers, etc. In an act of frustration I threw the wireless mouse against the wall, that was the end of the wireless mouse. Any other ideas? Thanks for the offer Raven Sid