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Ibuprofen? Maybe Not.

3 years ago
last modified: 3 years ago

Today's Chicago Tribune's Health section has a story from the NY Times. The headline is only part of the story, 'Common medications can prolong back pain'. That's an important part of the story, but buried within -- near the end of the story -- is something that must be causing pain to the manufacturers of these medications: "The tendency to use nonsteroidal anti-inflammatories persists despite their unimpressive performance. An analysis of randomized clinical trials found that these drugs had almost no benefit over placebos in reducing back pain." And I thought the main downside was that ibuprofen raises blood pressure!

The main thrust of the study is that over time, the use of these anti-inflammatories not only doesn't help the most commonly described pain, but can lead to chronic pain. Evidently blocking inflammation is not beneficial; better to use exercise, heat, cold, and massage to relieve pain, but let the body do its work. (The article notes that acetaminophen is OK, as it's not an anti-inflammatory -- not that I've ever gotten any relief from it.)

The study began at McGill University and was published in the journal Science Translational Medicine. The chief scientist at McGill was surprised to find that where people had intense inflammation, it and the pain gradually went away and did not return. Patients whose pain persisted had not experienced strong inflammation. Thus, the conclusion that inflammation helps.

The article quotes several doctors lauding the study. One, Dr. Thomas Buchheit of Duke, hails the information as a paradigm shift, away from "....the unspoken rule that if it hurts, take an anti-inflammatory, and if it still hurts, put a steroid on it." He says we need to think of healing, not suppression of inflammation. Doctors would like a more formalized trial to confirm these conclusions.

To me, whether medicine will decide when and where to 'let 'er rip' with inflammation or not isn't as interesting as learning that these popular drugs have been proven to be next to useless in reducing back pain. Presumably tests were specific to back pain, but why would the effect be different for other pain?

A little help with a link, please?

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