You can purchase uneven T-mouldings for the areas where the floors are not a matching height. That is normally the way it is done. As for direction of laminate, you have a close match to what already exists but it isn't a match. Changing directions is about the only way this will look OK. A diagonal install would look REALLY good, but it will require 15% - 20% waste which you may not have enough on hand.

Here's the WORST thing that could happen. The floor will rip itself apart at the doorways. That's it. That's all. If that happens all you have to do is cut the planks in the doorway, drop in trim, tap the floor back together and off you go. The fun part is: winter is the SHRINKAGE time of the year. That means the summer will see the floor expand as much as 1/2" over a 30ft span. You could see BUCKLING in the summer rather than 'unzipping' along the edges of the plank. It's your call. You have VERY narrow pinch points. That means you need to do ++ door trim (1/2" expansion gap at ALL vertical obstacles = door trim). How good does that look? That big fat 1/2" gap around the door trim?

Please provide a little more background to your question. You will never successfully match real wood to man made…

Well of course you can do anything you want. However, standard recommendations are to never place fake wood next to real wood. (Fake wood means LVP, laminate, wood-look tile, etc.)