I prefer horizontal on the walls as it seems more "natural" and "relaxing" (at least to me), to have them flowing around the room rather than pointing upwards -- particularly if you are doing a brick pattern -- and I wanted a horizontal accent stripe. When I think of rectangular tile, even large format, I think about bricks...and you wouldn't lay bricks in an upright orientation. However, if you are set on a vertical accent stripe, then it would probably look best with a vertical tile pattern. Or you could flip to horizontal, like I did. For the floors, the easy way is to do squares so that you don't have to worry about which way they flow. Here is a picture of my master bathroom, which has 12" X 18" on the walls, 12" X 12" on the floor of the shower, and 24" X 24" on the floor of the rest of the bathroom; my wall tiles are laid in a stacked pattern rather than a brick pattern: A couple of points: 1. My tiles were all dead flat, so I could have laid them in any pattern. However, many large format tiles have some slight bowing which can cause noticeable lippage when laying them in an overlap pattern, and this is usually emphasized by the down-lighting from the ceiling fixtures which creates shadows on the walls of the shower along parts of the grout lines. You can test for bowing by putting pairs of tiles face to face and see if there are any gaps or rocking at the edges, or gaps (light) showing through the center. However, regardless of how flat they are, the best way to avoid lippage problems is by doing a stacked pattern because sets of tiles typically bow in the same manner (such as having a slight hump in the middle). The worst situation is if some of them are flat and some are bowed as you will have lippage unpredictably all over. 2. You talked about doing 2" X 2" mosaics on the floor, and that is about right for a standard drain in order to get the slope right, and have good traction from the grout lines. However, if you want to use a larger format tile on the floor, you can with a linear drain, either at one end of the shower or in the center because the floor can slope toward the drain in a flat plane. Here is my shower floor with the drain in the center: If you put a linear drain in the center, the total amount of slope the floor has to have is half as much as having it at one end. A large format shower floor also has the advantage of far fewer grout lines to keep clean, but it requires tiles that have a wet static coefficient of friction (COF) or 0.60 or higher so that there isn't a slipping hazard; the COF number should be on the box, or the spec sheet, or available from the manufacturer or distributor for the specific tile.

@Design Girl Should I stagger Option B or look cleaner not stagger Option B? I have a few more baths. Can you help check. My guest bath seems to be the wrong direction or since my shower wall tiles are horizontal, I should also go horizontal on the tiles. Please help with powder room. Option A or Option B. The direction is so confusing to me. Thank you.

Source - https://www.hunker.com/12610437/which-direction-should-wood-floors-run Horizontal If you have a room that is narrower than it is long, it can end up feeling closed in. Laying hardwood flooring vertically in this situation would make the illusion even worse. To combat this problem, lay the flooring horizontally. This draws the eye from side to side, instead of down the length of the room. Just like a horizontally-striped shirt can make people look wider than they are, the horizontal stripes created by the floor boards have the same effect on a room. Vertical Vertical flooring is the most common orientation for wood floors. If the room is not overly small, floorboards that are placed vertically will work just fine. If the room is wider than it is long, laying the flooring on the vertical will help create the illusion of length in the room and balance it out. The only instance in which a vertical orientation should not be used is the instance above, when the width of the room is very narrow. Diagonal Diagonal flooring adds visual interest to a floor and can make the space seem larger. The eye is drawn across the room, creating the illusion of greater width and length. This orientation works very well in tiny rooms where both length and width are an issue. Diagonal flooring can also be used simply to make a floor pattern more interesting or to create a conversation piece for the room.

Horizontal sounds good t me. If you had real wood planks they would be a lot longer than 36" and you would cut the ends. Make sure you have a skilled tile installer who can lay this out first, then cut. The cuts should be in the corners so it doesn't matter. Your real challenge is going to be making sure the variety of designs on the tile look right since you're cutting off a lot of design that was intended to make it look right. That can be accommodated by a skilled tile installer who knows to look for that. You'll also have a lot of waste to make it look right, but it will be worth it. BTW, not so odd to have the vanity in the bedroom in houses built in the 80's. It was a thing for some reason. Didn't seem very functional to me, but in my past I looked at a lot of houses that had that. Good luck on your project.