The size of the pic isn't relevant - the center of any picture (or arrangement of pictures) should be more or less at eye level around 58 to 62 inches.

I wonder if one picture of that size might not look a little lonely, unless it's an important and lively piece of art. You might try stacking two with about two inches of space between them. They don't have to be the exact same size.

Here is a helpful article

https://www.houzz.com/magazine/beautiful-new-painting-now-what-artful-hanging-tips-for-the-home-stsetivw-vs~13670

Yes...center of one piece or a grouping should be at about 60". For years I hung art too high. Such a difference when done right.

Thank you all for the comments. It is a photo of my mom but now I am wondering if I can combine it with something else above or below so the wall doesn't look so empty with just that frame. Any thoughts?

56"-60" from the floor is recommended height. if it seems to small, have the picture put in a bigger mat and frame. 13x16 seems a bit small for that spot. if you have two of them, you could stack them. or do the one pic at 16x20. that should be a better fit.

No disrespect to your mother, but a family photograph hung on a wall in the living room does not have much decorative impact, and would be better placed in a hall or bedroom. For the living room, colorful paintings would be much more interesting and give life to your space.

Ingrid no disrespect taken and as a matter of fact, that is a very good idea. I think that is exactly what I will do. Thank you