My first thought was to put a large tack board there to hold a revolving display of your children's artwork.

Could you add more shelves?

I bought a used TV wall unit for my art room and bought IKEA stacked black mess drawers for the sides and black stackable metal draws for the big TV section. You would need to secure them or something like it so the little ones couldn't pull the whole thing out. However, it's great storage and could be good for puzzles, art projects or other little parts things. You have room for bigger drawers in your giant wall unit. Great way to clean up kid toys fast and out of sight.

I don't know anything about them, but I believe there's such a thing as tv screen protectors.

First thought is artwork hung like current owner and two storage baskets in place of tv.

Do you plan to have a tv somewhere else? There are decent educational shows on for kiddos they might want to watch, like pre-dinner time when you are busy, and I would want 4 kids under 5 right near where I am, probably on the main level, so I can easily see what they are doing

The fingerprints are fine, I think they need the tv too.

Shelves and storage baskets. What are you using the room for?

What about a mirror?

I assume with 4 kids all under the age of 5, you are putting a TV in a different family/play room? I would not have survived (or showered) during the toddler years had it not been for the electronic babysitter, I mean, TV.

You could do something like this. Upper Center pocket doors and regular doors for the rest. A wood worker could knock that off in no time. Keep a TV in the top section.

If you find it dark , paint it.

It would be so much easier to keep tidy than this.

Thanks everyone for the ideas. I will show this all to my wife and see what she says. Rebeccamomof123, you found what I had been looking for--a built in with a big open area for a painting or the like.

Yes, we will have a TV still in the basement. Although, our kids seem to only watch it when they happen to notice it (which is why I am trying to put it in a less central area of the house). We might find this doesn't work and we want the TV back, which is why I want to not do anything too permanent. I considered putting in another window like the two on the sides! But we might find this idea of no central TV to be folly. We will see! Thanks.

fish tank

You could also put latching cabinet doors on it for out-of-site storage.

I like Justerrilyn's idea -- small cabinets. Perfect for stashing Legos!!! And other kid toys!