I am not too proud to admit that that is way over my head. Good luck. Hopefully some one dumbs it down a little.

I may be wrong but I think this shows how these genes react with sulfites. If you have one of these genes or mutations your body doesn't produce an enzyme that breaks down sulfites in the body which creates a build up which may cause some problems

.......The MOCS2 gene mutations involved in molybdenum cofactor deficiency likely eliminate the function of MOCS2A, MOCS2B, or both, although in rare cases that are less severe, some protein function may remain. Without either piece of molybdopterin synthase, molybdenum cofactor biosynthesis is impaired. Loss of the cofactor impedes the function of the metabolic enzymes that rely on it. The resulting loss of enzyme activity leads to buildup of certain chemicals, including sulfite, S-sulfocysteine, xanthine, and hypoxanthine, and low levels of another chemical called uric acid. (Testing for these chemicals can help in the diagnosis of this condition.) Sulfite, which is normally broken down by sulfite oxidase, is toxic, especially to the brain. Researchers suggest that damage caused by the abnormally high levels of sulfite (and possibly other chemicals) leads to encephalopathy, seizures, and the other features of molybdenum cofactor deficiency.......

I have an allergy to sulfites, although now they don't affect me as much as they did when I was a teenager but I stay away from certain foods and wine that contain higher levels

Thanks, cherryfizz. That wasn't too bad. Don't think I could explain it myself but I followed this OK.

It was explained to me that some people with one or more of the CBS genes (on the list) are unable to process sulfur/sulphur (take your pick of spellings) properly. When they eat sulphur-containing foods (which are good for most people), the unprocessed sulphur builds up, creating ammonia and destroying serotonin. Not a good situation.

I've seen sulfites mentioned in this discussion too, but I don't know enough about that to comment.