I got my initial health results back. The ancestry component is still being finalized. Nothing too much to report. I do carry the gene for celiac disease and that's about it. I also found out that I am likely to metabolize the drugs used to treat things like h-plori too quickly. This is good to know because it's something that I may need to deal with at some point. I am prone to ulcers and I do carry h-plori. I haven't really looked into it in depth, but later on tonight I'll look into it more deeply. I did find it funny that I am very unlikely to flush due to alcohol when I flush pretty much after the first sip. So that I noticed was not correct.

It could be that it's not incorrect, exactly; you could possess the gene, but it isn't "turned on." Perhaps this is how some people are carriers of certain diseases, but never get symptoms themselves.

My report said I have a gene that makes it impossible to smell asparagus in urine. Uh, no. :-)

There were other things like that as well.

That's true Alisande. I hadn't looked at the gene breakdown before posting. Just a brief review.

I'm wondering if it could also be due to the fact that I just have skin sensitivities. I get the same way when I am in the cold, wind or even when I am coming down with an illness. It could just be some sort of immune reaction.

I was right about having lots of fast twitch muscle fibers. I carry both genes for that. I build muscle very easily. I'm short but am very strong. My eldest refers to my arms as "man arms". LOL I was very good at sprinting when I was younger and this explains why I was always terrible at long distance and had no endurance. When you tie it into genealogy it's interesting because I had many ancestors who were stone masons, which is a job where you'd need to have strength.

I was also not that surprised to find out I am a fast caffeine metabolizer. TMI but I don't even need to finish a cup of tea and I'm running to the bathroom. My dad is the same way and so is my sister's boyfriend. I was thinking about giving up tea but now heck if it says based on my genes that 1 cup per day is better than no cups then I'll keep drinking it. No point in depriving myself for nothing. ;)

Also check out your MTHFR (snps C677T and A1298C) gene. It has to do with how you metabolize folic acid (or don't, as in my case). You can do this in the raw data. I flush with alcohol too and don't have the gene for the true alcohol intolerance. It is a histamine reaction with me but I can drink a sparkling sweet wine without any flushing. Very weird. LOL, the more I learn how my body reacts, the weirder it gets.

If you are interested in the athletic aspect athletigen.com has a free download for you to discover how your genes contribute to your athletic traits.

I'm 2.6% Nethanderthal and maternal Haplogroup is in T2a and . "An offshoot of T2, haplogroup T2a, can be found at low levels in Egypt and the western part of the Arabian Peninsula. Although extremely rare outside the Near East, T2a has been found sporadically in Iberia, France and Norway."

Cookie- I will for sure check into it more. Right now I'm just browsing the data here and there otherwise I'd be sitting here for hours. They are still loading up a lot of the details too. I didn't even get a notice I just happened to sign in and found it was there.

Yes, the MTHFR snp is interesting, and not uncommon. There's a ton of information about it online. Important to note that folic acid is the man-made, synthetic form of folate, and not well tolerated by those with MTHFR mutations. True folate is what we need.

Another potentially useful one to know about is the CBS mutation. Two of them, I think. Some (not all) people with this mutation deplete their serotonin levels when they consume sulfur. Sulfur is an important nutrient, found in many different kinds of foods, so it's a complex issue. I don't know much about it.

Littlemonkey, sounds like you have an interesting Haplogroup! Mine is not unusual, coming from northern and western Europe. I have around the same percentage of Neanderthal--not a bad thing to have, as they tended to be long-lived.

I never heard of fast twitch muscle fibers, but will have to look into it. I always said I put on muscle quickly--like my dad. Although it certainly isn't true this year. Maybe those genes got tired and left. :-)

They are still uploading the raw data so some stuff isn't up yet.

I learned about fast twitch and slow twitch way back in high school because I took every gym course I could in high school. When I was in high school it used to go up to Grade 13 here so I took gym in grade 9, 10, two in 11, 12 and OAC (13) which was a kinesiology course. In grade 12 I was recruited for the track team. I did 1 month of training where every day they made us run several km at the start of the practice. 1 month in I quit. LOL I just was not built for endurance, told you. I loathed it.

I think they've now loaded up the MTHFR genes but I can't find the info with the SNP you've given above for folic acid.

There's not a whole lot of info on my mitochondrial dna group. I guess it's pretty rare especially in Europe. I suspect my group were the small group that travelled on to France and Norway area. Then much later on they must have at some point went to England. I have been told I look Scandinavian on several occasions. I believe it's just due to my cheek bone structure though, which is high. It's going to be interesting to see what they come up with for the areas they have when the breakdown is finished.

It will be interesting to share this with my mom. She seemed interested on the weekend, but she's quite religious and not sure how she feels about the whole migration. I think it threatens her beliefs a little bit. Wish I could share it with her and she believe it.

Ok found the SNP C677T is rS1801133

A1298C is RS1801131

For C677t - am AA whichI believe is a risk. I wondering if this is the one that there were studies into pre-eclampsia, which I had with multiple pregnancies. I'll have to look into that further.

For the A1298C I'm TT, which I believe is not the variant that puts you at risk.

Wait until you get some free time. Wow, you can really do a lot of research on so many things. My biggest surprise with the genealogy aspect was there was (nearly) no French. My grandfather was Quebecois and French came up as 1%. No one in my family believes 23andMe is accurate now. I hope to get more involved in genealogy later in the year but there is just no time at the present to figure this out. Was he adopted? His lineage migrated to Canada many, many years back? What? My mom gave up most of her religious beliefs, she's just stubborn lol.

For convenience sake you can go to the forum and there is a thread on MTHFR - Do you have it. All you have to do is click the snps in the entry paragraph and it tells you right there. I was totally lost when I first started out.

Thanks Cookie, I am looking through that forum now. I pretty much just get the early mornings to really have uninterrupted time. You are so right it IS a lot of info, but I did expect it at least. I can't imagine if someone didn't know what they were in for. I'm sure it is too much for some people.

I should have French on my dad's side for sure. I do know some that came over to France and settled in Quebec and on another separate branch I have French that settled in Pennslyvania before coming up to Canada in the early 1800's. I'm sure the percentage is low though with my dad's very mixed European background.

I'm not sure on my mom's side. Of course with this Haplogroup T2a it could very well be I had a long line of "French" before they settled in England. My mom's side is a lot of Foreign Protestants who came to Nova Scotia around the 1750's. They were mostly from Germany. There's also a great deal of English in there. There's little bits of Irish. I keep checking throughout the day to see if it's uploaded despite the fact that they say it could take 2 more weeks. I do like how they release things as they have it ready. I've been very impressed with the speed of it all.

My dad's side I should see more diversity. If there is any Native American it would finally put some rumors to rest. My dad looks quite Native (just using the term broadly as a group) and so did my grandfather. I looked at a few old pictures and so did my grandfather's mom. We haven't found any evidence from records though. It's been a puzzle in our family. I feel like it could just be from Dutch roots, which some do have that dark olive skin, dark eyes and hair.

My understanding is that 23andMe tells you where your ancestors were living 500 years ago. Cookie, does your family insist your grandfather's line was French forever? A lot can happen in 500 years.

MTHFR.net, run by Dr. Ben Lynch, is an excellent source of information. Here's a clip from that site:

Supplemental and enriched folic acid foods should be avoided by those afflicted with MTHFR C677T mutations because the MTHFR mutation has partially destroyed the MTHFR enzyme which is required to process folic acid completely.

Natural foods with folate should be consumed by all with MTHFR mutations as food folate helps make other forms of folic acid which are needed for various functions.

Those with C677T MTHFR mutations do not process folic acid into 5-MTHF.

If folic acid does not turn into 5-MTHF, folic acid levels build up. Elevated folic acid has potential to stimulate pre-existing cancer cells.

That said, it is unwise to provide supplemental folic acid to anyone with MTHFR C677T mutations.

Cookie - I uploaded my info into athletigen. Very interesting.

I agreed with the majority of it. And it seems I missed my calling as a power athletic. Ah shucks. I though it was very interesting under the aspect of if you are likely to train and it says that I have the gene that creates greater temperature changes during exercise. This is so true. I will get hot very quickly and flush where my face feels like it's burning up. I'm only a few pounds over weight too and I do physical (non-workout) activity everyday. Also not sure if this is related but I do have an allergic reaction to exercises. I get itchy all over my body. I've been this way for as long as I can remember.

I'm sure by the time my kids are my age, there will be even more research done to prove, disprove, and find new links. I will definitely be sharing the MTHFR c677T mutation info with my family. I'll have to get software to analyze the raw data, it would just take forever to do it on an one at a time basis.

"Also not sure if this is related but I do have an allergic reaction to
exercises. I get itchy all over my body. I've been this way for as long
as I can remember." Me too!! I hate it and it is tortuous. It is called exercise induce urticaria. It is histamine related so if you have an event where you do not want this to happen, I found an anti-histamine worked. I spent a lot of time in my youth at dermatologists because of psoriasis and I would bring this up and it was always something except a diagnosis - dry skin, materials of certain products, detergents, etc, etc. Nothing worked. Gluten free seems to work for me to keep it at bay. I haven't had an episode in awhile now. Anyway, on athletigen be sure to check out my dashboard at the top - even more info. BTW, I am a power wimp with a great metabolism. Really though, I do find myself quite strong for my size.

do you want to find out how your ancestors made it out of Africa and into your present location? Try the Smithsonian's Genographic project...https://genographic.nationalgeographic.com/

cookie, I was allergic in a similar way - just that I reacted to sudden change in temperature and broke out into large hives. It managed to go away after some time. My way of handling it was to take cooling showers (when I got too hot and itchY) and take some antihistamines. When I would jump into cold water (pools), Id break out too but as my body heat normalized its temperature, the hives also would disappear and I was fine. re psoriahsis. My cousin has it and she reacts to anything that is of the nightshade family - that is potatoes, tomatoes and eggplants.

Yes that's what I believe it is, never diagnosed from a doctor though. I'm going to have to go searching and see if there is a specific gene that they believe is linked to it and show hubby. He's never come out and said he didn't believe me but always had that skeptical look. It doesn't matter what it is either major workout, brisk walk or even sex. I have environmental allergies to everything so heck, why not be allergic to physical activity as well. LOL I've been lucky that's I've never had hives from it, more like something similar to heat rash, but not quite.

I had looked into the National Geographic one in the past but $200 is pretty steep for what you get, unless it's changed since I checked it out.

Editing for my terrible typing skills tonight.

Results came in for ancestry so overall pretty quick process. I'd recommend it for anyone interested in Genealogy to add to your files. I sent the kit in the Friday after Mother's Day and there was a Canadian and US holiday in there so pretty darn quick.

I went ahead and purchased the promethease report. Any tips for the best way to arrange the data or go through the data? I was thinking of printing it out since I'd like to share some with family.

Let us know your thoughts on it. I'm curious.

I'm still going through it (lots of data obviously). I'm just going through a little at a time in between doing chores. For $5 it is definitely worth it. The time saving alone is worth that much. Of course I think if someone is a worrier it could be a negative thing, because those people may feel they are doomed and not understand it doesn't mean you'll get something. Some genes seem to contradict one another. It's also import for people to realize that the info is based on scientific studies which we all know can change over time. With that said, a lot of the info I have read so far does correlate to my family history. Many genes seem to point to a higher risk for heart disease and I have several that are also higher risk for schzioprenia which given the fact that an uncle and sibling have it, we figured it was at least in part genetically related and genetic links to stomach, colon and bladder cancer. I also do not metabolize folate, beta carotene or vitamin d well so that will be something that I can and will change. Some of the plus' I have read so far is that I am likely to have more good HDL cholesterol and have several long life genes. In doing genealogy I did find many long lifers even in the 1800's getting close to 100. That I believe is more from my dad's side. I do think a lot of the bad genes come from my mom's side. There is so much to go through and look more into but it's far, far more in depth than the info you get from 23 and Me where the details are broken down.

Oh and it said that if I did cocaine I would be less likely to become addicted. Good to know. LOL

hi, it's more to do with body heat rather than activity related allergy. However avoidance doesn't work and makes things worse in the long term. Its far better to workout and let your body 'learn' that heat is not the enemy... (allergy is an overactive immune response)

Ianna, that was just a bad joke above. That's why I mentioned it was more like heat rash. I mostly get it on my chest and my thighs. Although I don't do workouts, I am far more active than the average person on a daily basis because I have to do everything on the farm with manual labor since we don't have a tractor. I'm in the best shape of my life right now. I have a few extra pounds of fat of course, but at 17 years old I never would have been able to handle the work I do now. For example today I had to carry 3 female goats that weigh roughly 80 lbs each into our outdoor pen. I never would have been able to do that 20 years ago. That was 80% of my whole weight. haha

Should I be happy or sad? homo sapiens gene (not
Neanderthal) 0.1
I did the Promethease test And I am totally lost. It will be YEARS before I find everything on that site. I've already played the youtube several times.

Imhappy - that is pretty low especially if you have European in you.

Ancestry says:

Europe
100%

• Europe West
  62%
• Ireland
  17%
• Great Britain
  8%
• Scandinavia
  5%
• Trace Regions
  8%
• Finland/Northwest Russia
  3%
• European Jewish
  2%
• Iberian Peninsula
  1%
• Europe East
  < 1%
• Italy/Greece
  < 1%

Which company and where did you find your Haplogroup? I've been looking until my eyes cross for it and I don't see it.

promethease says I don't/won't have dementia/Alzheimer's. Whew! I was wondering if it had started already. Guess it's just bad memory. Like you, some results canceled each other out, some were just ho-hum. Most were interesting. I don't metabolize Novocain and have to get it an hour before any dental work. There's a list of stuff that "doesn't work" for me like it does the general population so if/when I ever get prescribed anything I will check the list.

I printed out the - drug list?? - or something! I did a highlight all, paste to word, print but maybe you can print right from the new window that opens. I'm working on firefox which I'm not used to and some times I don't get the options I expect.

And I just saw this on a blog. I haven't looked at it at all because I knew I'd get so far away from my thought of posing it here I thought I'd better post first.

http://genesforgood.sph.umich.edu/

I wish we lived close enough to get together in person and hash this stuff out!

I used 23 and Me for the Haplogroup. My group was T2a, which is a pretty rare group from what I was reading. I guess my female ancestors weren't a hardy bunch or great reproducers. LOL I am wanting to look more into some of the info on promethease. It says I am a homozygous for a gene that is link to rheumatoid arthritis. My g grandmother on my dad's side had it bad by around and got it in her early 30's and my uncle on my mom side has it. So I do want to look into that a little more I am going to up my folate because of the results and my beta carotene and I'll for sure be taking d supplements now all winter. We're not terrible eaters but we could be better and now I know I need to eat more of certain things.

According to the speculative report my ancestry breakdown is

99.3% European the following is a breakdown for European

53.5% British & Irish

10.8% French & German

3.5% Scandinavian

0.2% Finnish

26.5% Broadly Northern European

1.3% Iberian

1.5% Broadly Southern European

0.1% Eastern European

1.8% Broadly European

0.5% Middle Eastern & North African - showing for North African

0.2 % Sub Saharan African - showing 0,2% West African & <0.1% Broadly Sub-Saharan African

<0.1% unassigned

I need a promethease study group!

I'll join!

I ended up going through promethease. LOL, grim outlook - keep eating those veggies.

Since we're sharing:

76.2% European; 21.7% East Asian (very small fraction) & Native American; 2.1% unassigned with 2.7% Neanderthal.

Cookie, just remember that some of the results on promethease are just associated with studies that have been done that show those genes may increase risk factor. Sometimes the percentage is so small like instead of a 5% chance, it's now 7 % chance. Many of these studies are also based on survey questions which can be flawed. There are some that are more indepth scientific studies but just remember just because you carry a gene, doesn't mean you'll end up with the disease. Many times there is an environmental trigger to illness.

I do find it odd that nobody has the African DNA. Shouldn't everyone have that?

No worries here. I do have four of the conditions that I was at higher risk for (autoimmune related) but are under control due to diet and lifestyle with symptoms no longer presenting themselves. It's all good. I do believe the science is too new to be set in stone and be concerned about.
It is fun though.

I do find it odd that nobody has the African DNA. Shouldn't everyone have that?

I think the explanation is that 23andMe tells us where our ancestors were living 500 years ago. For those with European ancestry, the African period took place much earlier.

I got 100% European. No surprises except for 0.7% Scandinavian and 3.1% Italian. The Italian surprised me more than the 2.3% Neanderthal!

Well there has to be something I am missing somewhere then. I haven't found any evidence genealogically to suggest any sort of African heritage. I'll have to try and do more digging. I was assuming based on the fact that they also put Iberian in there that it was based on my haplogroup. If you go to the conservative view which is supposed to have 90% accuracy I have 97.4% Eruopean of which it's 6.4% Bristish and Irish, 48.5 % Broadly Northern Eruopean, 42.5 % Broadly Eruopean and 0.1% Sub-Saharan African. Then 2.4% Unassigned.

I think I need to talk my dad into doing this. I'd be able to see which side the African comes from.

Editing to add that if the test doesn't include the last few hundred years after the widespread migration, then the test is only for a window of 300 years or so?

From a post from 23blog

Hi Rick,
I think we've exchanged messages before, but I'll try and answer your question.
It's best to look at this in two ways, one is looking at deep ancestry which we can trace following your paternal and maternal lines. This links you to your ancestry back through thousands of years because there is little change from generation to generation on the maternal and paternal lines.
Then we look at your more recent ancestry, that is something that helps us connect you to close and distant relatives with whom you share a relative within the last five or six generations.
When we predict your ancestry we can do that by comparing your DNA to about 31 reference populations.
When we report back your ancestry it is not looking at deep ancestry but ancestry within the last five to six generations. Although you may be say Italian, you may learn something about your maternal or paternal haplogroup that gives you a deeper insight into your Italian ancestry.

So the African, Iberian results are from the Haplogroup.

My husbands test showed he has about a 45% chance of getting diabetes. He has since been diagnosed as pre diabetic. Mine came back with about the some % risk of venous thrombosis (blood clots) and both my mom and brother have had them.

I'm 100% European but my husband has a very small % Native American. Another friend who is white discovered she has a very small % sub sahara African.

happilady was this test from 23 and Me and was it recent. According to the person that writes their blog and posted the message I posted above that was written in the last few months, it's supposed to include Haplogroups. So that means anyone getting the test recently should have some form of African since all humans emigrated from Africa. So they are mixing newer genetic information to tell where your ancestors may have lived in "recent" times and the info from Haplogroups which is 10s of thousands of years ago.

So I opted in for the relative match ups and it is finally up. No close relatives, none with the same Haplogroup. The person that shares even the closest dna to me is 0.73 percent (that's less than 1% folks). LOL I guess my relatives don't like to do genetic testing.

I just had a realization about my haplogroup. In my own family it's pretty much ends with my generation's kids. My grandma had 7 kids, 4 of which were daughters. Of those 4 daughters the total biological grandkids are 9, of which are 4 girls. My sister and I both have boys so we've ended that line for our immediate family. 1 cousin has yet to have children, the other has 1 girl. Only potential of carrying on that line is if either of those two have girls. Maybe that's one factor why my maternal haplogroup is so small, more boys born than girls?

My relatives don't like to work on ancestry OR genetic testing. There has to be more of us Out There somewhere! All my ancestors had a dozen kids of which 3/4 lived to have children. As far as I've looked I'd guess 90% have children of my generation. Hard to say how many of those are living. Of the living, where are they? Hiding? Protecting their privacy? In the nursing home?

BTW Promethease said I had a lowered risk of dementia. So what's wrong with me? I CRS every hour of every day! I spend hours looking for stuff I just had a minute ago. Can anyone imagine what it's been like while I study Promethease, 23andme, ancestryDNA, GENmatch, Family Tree DNA, and the list goes on. The worst mistake I made was joining/doing all of them the same night. I should have done one at a time over a few months.

I don't have my haplogroup. How much effort/$$$ should I spend to get it? And if/when I know it, then what?

Imhappy, if you did it through 23 & Me your haplogroup should be there. It will just be your maternal side though. I'm not sure how worth it, it would be to go and have it tested if you don't already have it. It is pretty amazing that they can track details like that, but it likely won't help in a search for genealogy.

If you have 23 & Me go under your ancestry over view. Then click on Your Mother's Line. That is where it will say your haplogroup. It will explain how your group evolved and will link some famous historical figures or famous people to your group. For example mine T2a is an offshoot of T2. T2 is an offshoot of T. And if I remember correctly T is an offshoot of J. A historical figure with T2 haplogroup is Jesse James, yes the outlaw. It's really of no significance for me though.

I would like to do the genographic one as I'm curious as to my deep ancestry. I'm particularly curious as to my spanish ancestors background. There are rumours in my family about a jewish line or even perhaps a moorish line.

I am always fascinated by ancestry and have had the privilege of meeting someone who is a descendant of Genghis Khan (apparently there are millions of descendants worldwide) and also another who is a direct descendant of the first Emperor of China..

I'm finding the relative match up thing on 23 & Me pretty frustrating. It doesn't help that there is obviously nobody remotely close to me if the highest amount of dna shared is so small. The odd thing in all of it is that I keep seeing people with surnames for loads of surnames on my husband's family. Those surnames are not in mine. I joked to him that maybe we are related. Anyway, just wanted to share my frustration. I'm not necessarily looking for relatives anyway as I have at least to 4x great grandparents in all of my family trees, but I thought it might be nice if there were some closer relatives that may have pictures. Ah well, guess my family just doesn't like genealogy.

I have written off the ancestry matches. My matches at GEDMatch answer me AND they have my family names in their tree!! BO-NUS! All I have to do is compare the amount of DNA we share and where and I have a pretty good idea if they need to be contacted. I've had a couple contact me, too! At ancestry people don't answer, have private trees, have trees with less than 10 people in them, or no tree at all. I guess the ancestry advertisement of "just enter your parent's names and we'll produce your family tree" worked. If I'm really serious about family trees at ancestry I will do the search from the person page and choose family trees. I've had a much higher success rate doing that than following the match hints.

I'd like to see some pictures, too. Someone must have some. On another note, there is an "aunt" who is probably dead by now who is rumored to have 13 boxes of genealogy stuff she inherited from her mother and aunts. She wouldn't share with anyone. I call her insulting names under my breath. I bet she's dead and I bet it all went in the dumpster since she didn't have any kids.

Well found a distant match to my DNA. I think some of the problem with using the feature is that many people don't have very far back, perhaps a few generations. The match was on just 1 segment and 0.19% but it goes back to the late 1700s. I have higher matches but either no response or ones that say it's probably just chance. I don't think they realize that people did move from County to County in England. I kinda just said, "oh you're probably right". They likely didn't have as far back as I did anyhow. Or it could even be a connection to another surname that one of us are unaware of.

Imhappy - that would be amazing if you could come across all those boxes. Pretty selfish of her not to share. Just goes to show you can't choose your relatives.

Decided to take the plunge and join Gedmatch. The results are so disappointing. My relatives really don't seem to care about genealogy. Other than one person that is approx 3.3 generations away and 143cm of shared dna. The next highest is only 30 cm.

Is anyone else experiencing this with only quite distant matches. I'm talking hundreds of years for our shared relative. I've had better luck in the past when I use to use the ancestry message boards.

I've had better luck in the past when I use to use the ancestry message boards.

I think it's possible--even likely--that many people are actively involved in genealogy but haven't had their DNA tested.

That is true.