You can certainly plumb it "as is", but with consoles or pedestals, non-centered plumbing will stick out like a sore thumb due to it being exposed. With the drywall not yet taped and with what only looks like a couple of screws holding each sheet to the framing, removing the drywall and replumbing is an option. But it's a "pain versus gain" thing. How much $$ is it worth to you versus any aggravation that the off-centered plumbing might cause you in the future? Were it my house I'd center the plumbing. I'd not be able to tolerate something that out of whack that would be exposed. But that's just me, and I can do all the work myself. If a vanity was going in there, an argument could be made to leave it as is, as it'd be hidden within the confines of the cabinet. So it's really a personal choice. Your choice of a console is driving you to a $$ repair versus an unattractive aesthetic.

Thanks, sabjimata, akchicago, cilantro, and pinch me. I think I am going to stick with the right-side installation and center my faucet, even though it means the stream will never reach my drain. Anyone who wants to scream "Nooooooo!" at this point, please feel free... (notwithstanding pinch me's great point about marching to my own drummer, which can never be said enough... thank you, pinch me!) akchicago, your points about pull-out/pull-down sprayers vs. side sprayers are all right on the money. I was actually aware of the disadvantages of side sprayers -- thanks to this site -- and bought one anyway. Why? Because when the end of the faucet's nozzle is a spray head, and its spout is harboring a spray hose, the whole thing becomes quite beefy and contemporary-looking, and my husband didn't think it would look right in our 125-year-old kitchen. So form won over function this round, and I am okay with that... though I'm sure to have the occasional pull-out envy when my thumb gets sore from pushing down on that little button... Still trying to decide if it's okay to cheat the faucet an inch or two left of center (to align with center of window pair), now that I will have the drain on the right. I mean, if the stream's not going to hit the drain anyway, does it matter where it hits? Or is there a reason to keep it as close to the drain as possible, even if it's no cigar? Thoughts?

colorlady's right - depends on where your drain is. My faucet is not centered on the drain, and I find that a minor annoyance. Just something I didn't think of beforehand.

We have a center drain with an 18" trash and recycling setup underneath it. Initially thought we would need a side rear drain, but it worked! What makes it feasible is the lack of a disposal, so if you don't plan to have one, you might be able to pull it off. It really depends on whether you can fit all of the rest of your under-sink gear on one side of the sink (minus a bit in the middle for plumbing). We don't have any of those, so not sure how much space they take. If you're doing two half-depth bins side by side (on both sides of the sink) it might also be different--ours are two front-to-back so they take up 100% of the space on one side but nothing on the other.