I had been on Prolia for three years with no reaction issues, and an improvement in my bone density tests. When I saw the endocrinologist last week for my shot, he said that it was time to have a Reclast infusion instead. So I did. OMG, the aches and fatigue were unbelievable. I think I slept 20 hours the day after. The infusion would be once a year, and I am already dreading the 2026 event. From what he said, I would do this for three years and then go off meds for a few years, and see what happens. I am very disheartened and wondering if I made a mistake, but I went with the expert opinion. The infusion itself was uneventful--they even offered me drinks and snacks. I had to take Tylenol the day before, the day of and the day after, for the aches. I don't think it helped anything. I had to drink a quart of water before the infusion. Apparently the meds can affect kidney function. I don't know what to tell you. My friend had Reclast and had the same experience.

I’m on my second 5 year cycle of Fosamax taken once weekly. I had a two year ’holiday’ after the first 5 years of taking it. I’ve never had any issues at all. Scans showed either stable or slight improvement. I resisted taking anything then asked why not something like Prolia. The endocrinologist said Fosamax is still the gold standard & has the fewest problems. I agreed to start taking the drug when she told me of a patient who broke ribs from the simple act of a hard sneeze. I don’t know what my next steps are in about three years when I complete this second 5 year cycle. My PCP said ten years is the lifetime max for Fosamax.

PC recommended Fosamax or Actone.

My BIL has had good results with Prolia.

There's good news and bad here.

I'm 84. My oncologist and my primary nagged me to start Zometa infusions. I did two. The second made me so miserable that I quit. I'm already loaded up with toxic monthly infusions plus daily oral meds against Multiple Myeloma (a blood cancer). At present I require strong narcotics for the pain of scoliosis, collapsed vertabrae, and de-mineralized shoulders. IDK how much of this is age, how much the cancer, how much the treatment against the cancer.

My DH is 87. He has taken Fosamax (a pill) weekly for a year. He feels it has aided his only arthritic pain -- in his neck.

We have both had teeth extracted in the past two months, using two different oral surgeons . Both are completely against these products. My oral surgeon said it doesn't matter that I had only two infusions of Zometa. "It's IN you, and it's affected your jaw," he said. My DDS is currently making an 'appliance' to replace three extracted teeth.

When I go to the cancer center for the MM infusions, I see many women having Zometa infusions. My treatment takes three hours. They take only a few minutes. It must be quite lucrative for the hospital.

Speaking of lucrative, is there a dentist or oral surgeon left who isn't cashing in on Botox? I've seen quite a parade of women and teens in and out while I waited in dental and surgical offices.

I had reclast once and was so sick 102 fever, vomiting, pain, hand curled into a C etc so i never did that again. I did nothing for a couple of years then started prolia. I have had improvement and my dr told me today she wants me on eveniity (once a month shots) for a year to get more improvement and then back to the prolia to maintain it. I am a little nervous but will try it. It is possible to get back to normal bone density.

I was on Evenity for a year then once on Reclast to finish. Something to do with sealing it up. I just had it done last Friday. No more for at least a year. I had no side effects. After my second broken hip I was willing to try anything.