That's an interesting idea - I wonder how much more it would cost to do that - would I be able to move the toilet that far forward? It's a townhouse and I'm just not sure about the quality of the original construction or if I'd want to be in the bath tub when someone else is walking through to get to the closet. I'll keep it in mind but I think I'd rather stay closer to where all the water and plumbing lines are currently located to keep costs down.

Here’s a pic of the space - originally a bedroom that will be converted to an en-suite main bath. The window is awesome, but are removing it and extending that wall out to absorb a small “patio” area (it’s great for letting light into this room and hallway, but that’s about it). Would plan to add a skylight in that window area instead. The overall footprint available for the bathroom is 16’ L x 11’ W. The door will go on the side the “photographer” was standing, and we’re hoping to create a little closet that side as well (ie, between the bathroom wall and bedroom area the “photographer” is standing in).

Practically speaking, I prefer layout 1. I can't see having 2 water closets in one bathroom, and that also cuts down on the size of the shower. I prefer the free-standing bath being against a wall, rather than in the middle of the room, where there's no place to place products or towels. I also think the split sinks/vanities give people more privacy, than having them sinks side-by-side. Layout 1 also takes advantage of that large window, providing light to the entire room, not enclosed in the shower.

Both our existing and new bathroom are similar to your bathroom 3--rectangles with all the fixtures in the main space. We are using the same lighting for the new one as for the current, since we are happy with it. For that, we have a fan/light combo centered in the space, and then two sconces on either side of the medicine cabinet. In the new bathroom, we're using a humidity sensor switch, because our state's current code requires either that or a sensor in the fan itself. (The fan sensors are supposed to work better, but don't allow for manually turning the fan on and off, and we wanted to be able to do that.) In our current bathroom the fan is on a timer (but my kids constantly forget to turn it on, so that's high on my list to change out based on how we like the sensor switch in the new bathroom). Our sconces are on vacancy sensor switches (also required by our state code) and both are switched at the vanity rather than at the wall with the ceiling light. I had actually forgotten until I read through an old thread I posted here that this was not our preferred configuration when we updated the electrical in the existing bath 8 years ago--but as it turns out, we really like that setup so replicated it in the new bath. In your Bathrooms 1 and 2, though, it looks like you have walls separating the toilet room and the shower. Assuming those are full walls, you would want lighting for those areas separately from the main room. There, I'd probably use a fan in the shower area, and then light the toilet and sink areas separately.