I'd say go for it. Make the jambs out of solid 5/4 stock with the door rabbet cut out, so no applied door stop molding. The heavy jambs will be such a great upgrade over the stuff they send out with prehung doors, not to mention the unspeakable garbage of split-jamb doors.
You will need to figure out how to mortise the hinges accurately, and troubleshoot hanging problems like hinge-bind, and the one tool to invest in (for rabetted jambs) is a #78 stanley rabbet plane so you can plane tight spots on the jambs in place, after the doors are hung. A real time-saver. You will probably also want a #10 1/4 jack-rabbet plane (yes, seriously) to clean up the rabbets that you make with a table saw.
Casey

Sounds like a fun idea and I think it could turn out well, but it depends on the style of the house. And have you been buying doors that are all the same size? (I bought a number of stained glass windows and used them as transoms over our interior doors. They are not all the same, and I think they look wonderful.)

I love the idea too. If you can have them all retrofitted to work, I'd do it! Different knobs may work too.

What is the style of the house? If it fits the style, I would do it.

The style of the house is a ranch style. Very simple lines. The interior will be a mix of new and old. We are going to have an open concept with kitchen and family room and nook and then a dining room. My hubby is going to build a 3.5ft. by 12ft. harvest table. The chairs will be different sets. I am looking for an old hutch to redo and then we will build a buffet table too. My lights over my island will be industrial looking barn lights.

My style that I like is pretty much what Joanna Gaines from Fixer Upper has her house like. Whites, gray's, wood and industrial look.

attaching a copy of our plans, we did redo the master bath.

I really haven't found it to be all that much more difficult to make door jambs from scratch vs futzing with pre-hung to make them right and you have a lot more freedom to make stuff that actually fits the first time. So by all means, do it! If you can use the same hinges a router jig to make the hinge and lock mortises is nice, but it's not so bad to do with a chisel

Sounds nice!

Do it. You can always replace them with boring doors in the future (if you change into a boring person, or have to sell or something).