Did they do any blood work -- BNP in particular, also the kidney tests, BUN, creatine and one or two others? Swelling in the extremities can be signs of kidney and/or heart failure, and then with the blood thinners and/or aspirin so many are on, any bleeding at all would be increased.

I wasn't familiar with INR, so I searched and from what I am reading, it sounds like a high INR would mean she may have too much coumadin and should have less, not more. Like I said, this is new to me, and I could have it backwards, but I would make some calls and double check.

This is from WebMD -- link below:

A method of standardizing prothrombin time results, called the international normalized ratio (INR) system, has been developed so the results among labs using different test methods can be understood in the same way. Using the INR system, treatment with blood-thinning medicine (anticoagulant therapy) will be the same. In some labs, only the INR is reported and the PT is not reported.

Prothrombin time (PT) and international normalized ratio (INR)1
Prothrombin time (PT):
11-13 seconds

International normalized ratio (INR):
0.8-1.1

The warfarin (Coumadin) dose is changed so that the prothrombin time is longer than normal (by about 1.5 to 2.5 times the normal value or INR values 2 to 3). Prothrombin times are also kept at longer times for people with artificial heart valves, because these valves have a high chance of causing clots to form.

Abnormal values
A longer-than-normal PT can mean a lack of or low level of one or more blood clotting factors (factors I, II, V, VII, or X). It can also mean a lack of vitamin K; liver disease, such as cirrhosis; or that a liver injury has occurred. A longer-than-normal PT can also mean that you have disseminated intravascular coagulation (DIC), a life-threatening condition in which your body uses up its clotting factors so quickly that the blood cannot clot and bleeding does not stop.
A longer-than-normal PT can be caused by treatment with blood-thinning medicines, such as warfarin (Coumadin) or, in rare cases, heparin.
What Affects the Test

Reasons you may not be able to have the test or why the results may not be helpful include:

Taking medicines that can affect the action of blood thinners (such as warfarin) and vitamin K. These include antibiotics, aspirin, cimetidine (Tagamet), barbiturates, birth control pills, hormone therapy (HT), and vitamin K supplements.
Having severe diarrhea or vomiting that causes fluid loss and dehydration. This may make the PT time longer. If diarrhea is caused by poor absorption of nutrients, vitamins, and minerals from the intestinal tract (malabsorption syndrome), the PT may be longer because of a lack of vitamin K.
Eating foods that have vitamin K, such as broccoli, chickpeas, kale, turnip greens, and soybean products.
Drinking a lot of alcohol.
Taking some herbal products or natural remedies.

Wishing you the best in finding out what is wrong.

Here is a link that might be useful: Web MD link

No, I'm the one who had it backwards. Her INR must have been too low. It was clotting too fast.

You probably had it right in the first place. What happened is her veins leaked the blood into the body parts. She may be eating something that causes the blood thinner to thin too much. Hubby uses the generic and I have to watch what he eats and drinks. Now has a warning about cranberries. Some things such as pistachios are fine in low amounts but cause bleeding if you eat too many. Half cup in his case. Ask her what she is eating and drinking then check it against the do not use.

Ask your doctor for a referral to another doctor that uses her insurance, his business office will know, then switch if you like.

I am also suspecting leaking from too much blood thinner... of any kind. You can add licorice to that list, Maifleur.

You might ask the doctor for a referral to a blood specialist.