Of course you can. You might also want to look into some of the single hole faucets. Some faucets like P-Pf's 'Ashfield' are sold as 4 inch spreads, but actually only use the center hole, have a plate that covers the outside two. They can be mounted either as single holes or 4 inchers.

Just a follow up with a picture since I always appreciate that as a poster. I wouldn't have done this without the knowledge gained from this forum! This is the new Delta Trinsic installed in my old sink. It is not the "touch" version. Looks good! Ignore the huge compost bucket on the counter. Makes me want to pull out everything now. Did have to use the expensive escutcheon and DH was able to pull out the useless hot water dispenser so we now have a soap dispenser (with a NeverMT, another awesome tip from the forum). Note on the function: works great with our less than good pressure. The switch from spray to stream stays where you left it when you turn on and off the faucet which I know is important to some people. Seems very solid and the pull down snaps in with the magnet with no dangling. Note on splash: it IS splashy in my less than 7" sink, but it is not nearly as bad as I feared. Totally worth it for the improved clearance with the high arc. When on, water goes straight down my centered drain. Note on the finish: "Artic Stainless" is great looking, coordinates well with my KitchenAid dishwasher and Whirpool Sidekick Fridge, not too shiny and not overly brushed either. Was able to track down the air cap in the same finish at Amazon. There IS spotting from water and fingerprints, so if that annoys you be aware, but it wipes away easily.

How do you plan to use it? As a water source? Hand washing? Or are you going to actually prep food at it? If prepping, then things will likely start out being pulled from the fridge, put on the island, and then washed, cut and either put in a bowl for serving, or put near the range for cooking/baking. I would think that having it face the fridge makes it most convenient to start prepping from there, also it's the widest work space and bigger is better when it comes to that -- hence, I vote fridge side. Unless it's a round sink, I'd probably not put it in the corner -- I'd end up with water everywhere if I did that.

Bob - that is exactly my new kitchen! Thanks for the picture. In our case the refrigerator is directly opposite your sink with an island in between. I was worried about the flow of movement from refrigerator to sink and back. KD thinks middle location isn't large enough to warrant a change. Your picture helped. I know my post would have been helped by pics but I haven't been able to figure out how to insert. Went to photobucket last week and wasn't able to sign up. Will try again.