Allowing it to dry well will help if it's an issue with rotting roots, but those spots in the top pic aren't what overwatering or too dry usually looks like. When Pothos gets too dry, entire leaves turn evenly yellow, starting with those nearest the roots. Some of the damage in the 2nd pic could be from rotting roots but impossible to say for sure from a pic. Just in case it is some type of fungus, try to keep the foliage dry when watering. Pothos researchers at FL U say sudden drop in temps can cause spots like that. My (main) plant that didn't get brought inside seems to have suddenly developed these spots too since we've had a few colder nights in the midst of much warmer days. (There are some more interesting cuttings I've gotten in trade recently and I've lost interest in devoting space inside to the ubiquitous one. Curious at this point if it can survive winter here, so put it in the ground a few days ago. Last winters' experiment of whether it can go 4 months without a drink was successful, though my house isn't as dry as most during winter.) Symptoms - Leaves have scattered brown patches, usually located in the center of the leaf. Control - Low temperatures or abrupt change from very high temperatures to moderate temperatures can cause this discoloration, especially if plants are succulent and growing vigorously. Maintain even, warm temperatures. Here is a link that might be useful: Pothos production guide, UFL

Yes, it has drainage holes- I left it in it's nursery pot. I put rocks/gravel at the bottom of the "decorative pot" that sits on the floor and the nursery pot sits on top of the gravel so it won't sit in water.

Your plant looks fine from the pictures. I water mine every week or when the soil feels dry. Don’t repot

First of all I think your plant needs more light. If you are watering it too much, the leaves will turn yellow and fall off. (Mine does). Also, unless you really like your plant to hang and trail, I would trim the hanging down branches about half way up. The plant will produce another branch from with little brown node at the base of the leaves (on the branch). and look fuller. You can put the cuttings in water and they will root and you can have another plant or two. About the brown tips, I think it just needs more light. Mine do best in an East window on a small console table.