there have been a multitude of posts about the harsh winter.. and the supreme winter damage on such ... can you be the only person who did not have winter damage??? ... but now have a disease??? i think ... as jean suggests... you are seeing an after effect... and solving such.. will not address the cause ... pic of the whole is a great place to start ... ken

I've had excellent results from cold-pressed Neem Oil (from Dyna-Gro, but any PURE cold-pressed Neem Oil will work). I mix 2 Tbsp. Neem and 2 tsp. Soap (not detergent, real soap) into 1 Gallon of water, and mist the plant, making sure to cover everything. This prevents sucking insects from reproducing, but doesn't hurt helpful insects. It has a faint garlic or onion odor, but it's not very offensive. Apply it twice a week for the first couple of weeks, and once every week or two after that. It will not immediately kill the aphids, it will take a couple of weeks for it to work, and you will need to continue to treat them. But it is safer than many alternatives. This will help with spider mites, too, which frequently show up when you're growing inside. As others have said, continue to try to spray them off the plant and squish them whenever you can. It will be an ongoing battle, an you will probably never get rid of them completely, but a couple here and there won't hurt your peppers. Good luck, and enjoy your peppers! :-)

Thank you for your reply!. We are in Dallas, TX . The vines are small, we just planted them this spring, therefore I am afraid that the insects will kill it. So far all we did was to sprinkle the leaves with the water from a hose, as you have suggested. We have other plants in our back-yard (flowers, bushes, pomegranates) - but the insects attacked specifically this plant... I hope that you are right and that the insects (or are they bugs?) will not destroy the whole plant. So far, there is no leave that does not have holes in it...

Agree with socks on 3rd, yellowing & soft leaves are most often waterlogged. The mix you have in that pot could be amended with lots more of sifted perlite or pumice, and you can even add some grit f similar size. The pot seems quite large at this stage, and therefore holds lots of soil - if it isn't draining well, there is your problem. First could be mechanical injury that is scabbed over - bites more likely by pests (perhaps some insects too, but snails leave slightly different pattern and also, quite often, a slimy trail - but check for anything as socks suggested). Or maybe something fell on it and scratch the leaf... 2nd plant -aloe or agave or something else? - I am not sure...that spots could have been also nibbled by pest and took longer to heal, or maybe bit of fungus got there - hard to tell for me. Watch if it does or doesn't spread. I see there was some damage to leaves on tips too, was it similar? And finally: yes, stuff happens outside (even inside)...probably impossible to have perfect plants, without any blemish whatsoever.