I'm married, what's sex?

I've been using MenoCream for 17 days. I notice no real difference in myself. I'm still pissed off at the world & I could eat everything in sight after 8pm. I am only using it once a day. I take PaxilCR for anxiety, so my anxiety is at a minimum. I truly believe there isn't a person I know that would want to be around me when I'm pissy. Any advice?

Progesterone, and all the other hormone treatments, have a slow gradual effect. Don't expect a sudden change, but wait 2-3 months and see if you can tell any difference. If not, then it may not be the cause of the problems you are having. I can tell the progesterone cream works for me because I get PMS symptoms on a regular basis now. Prior to my using it, I would go for many months without any hormone level symptoms at all. (I don't have periods due to a partial hyst at a young age). I would rather have PMS than no sign of hormone function at all, lol. Mrs H

Expanding on what others have said, the estrogen creams and gels for skin, as opposed to vaginal, use are prescription forms, made up by a compounding pharmacist to a prescription written by your own doctor (the pharmacist can help him with that if he is unfamiliar with how to write this kind of prescription). There are compounding pharmacists in Canada and they can make up these forms of HRT, but they are somewhat harder to locate (less common) than in the US. The main difference between using a topical cream/gel and using a patch is that the patch gives a steady release over the life of the patch (more or less) where the topicals give more of a curved effect, peaking after the dose and then dropping off till the next dose. Whether or not that makes a difference to any particular woman seems to be an individual thing: some dose with topicals once or twice a day and do fine; others have to go to multiple doses to avoid too much variation in hormone levels. The vehicle (there are a number of different cream bases, not to mention the gel) and where you put it (fatty tissue versus not) also affect the length and shape of the absorption/circulation curve. So, as with everything else menopausal, there's a lot of personal variation and you may have to experiment some to find the best one for your own body. There are, as Leigh notes, no effective over the counter variations on estrogen creams and gels.