Have you tried going to Toshiba support ?
Drivers & Updates
Touchpad
Then download and install the most current driver ?

Here is a link that might be useful: http://support.toshiba.com

For less than $10, you can buy a mouse with a cord and solve the problem. Or get another wireless one if you're ok with spending more.

Mikie,

Thanks for your response, I have d/l the most recent driver for the touchpad.

There must be a conflict between safe mode and running regular programs, I don't know where to look.

Any other suggestions?

Thanks,

Sidnee

Did the problem exist before the driver change?

Many advise against driver updates, there are risks and seldom benefits of doing so

fwiwi

My Lenovo now, and Toshiba's in the past, have had a couple of ways to disable the touchpad.

One is in the control panel mouse settings. Another was a key combo press.. Lenovo here is Fn+F6 to toggle the touchpad on / off.

If the touch pad is working in Safe Mode then a driver issue would not be the cause, and as you have indicated it's possible a 3ed party program is interfering. Norton Anti Virus does not run in safe mode and all of it's many drivers are not loaded in that mode. You could try from regular mode- disabling Norton and see, however this sometimes is not conclusive, because you are usually only disabling active scanning an a Norton driver or service is still causing issue. Norton's a constantly changing program with all it's up dates so it's alway's something to consider as with any Anti Virus when something works in safe Mode but not regular mode. One of the best ways to troubleshoot this issue is to use MSCONFIG, that's what that programs for and it may help to identify the issue, as described in the link provided.

Here is a link that might be useful: msconfig-utility

Snidely, I updated the driver after the problem started.

What was the make of this 'wireless mouse and keypad' that you Uninstalled ?

Perhaps their website support pages has some special uninstall procedure listed. You can probably email them and they will probably know right away what the problem is and hopefully have a simple fix.