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althea_gw

New study: Roundup

althea_gw
19 years ago

Here is the abstract of a new study of Roundup.

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Environmental health perspective

Differential effects of glyphosate and Roundup

on human placental cells and aromatase

Sophie Richard, Safa Moslemi, Herbert Sipahutar, Nora

Benachour, Gilles-Eric Seralini

doi:10.1289/ehp.7728 (available at http://dx.doi.org/)

Online 24 February 2005

Abstract Roundup is a glyphosate-based herbicide used worldwide including on most

genetically modified plants in which it can be tolerated. Its residues may thus enter the

food chain and glyphosate is found as a contaminant in rivers. Some agricultural workers using

glyphosate have pregnancy problems, but its mechanism of action in mammals is questioned. Here we

show that glyphosate is toxic on human placental JEG3 cells within 18 hr with concentrations

lower than the agricultural use, and this effect increases with concentration and time,

or in the presence of Roundup adjuvants. Surprisingly, Roundup is always more toxic than its

active ingredient. We tested its effect on aromatase with lower non-toxic concentrations, the

enzyme responsible for estrogen synthesis. The herbicide acts as an endocrine disruptor on

aromatase activity and mRNA levels, and glyphosate interacts within the active site of the purified

enzyme, but its effect is facilitated by Roundup formulation in microsomes or in cell culture. We

conclude that endocrine and toxic effects of Roundup and not only glyphosate can be observed in

mammals. We suggest that the presence of Roundup adjuvants enhances glyphosate

bioavailability and / or

bioaccumulation.

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Here is a link that might be useful: hormone disruption and fetal damage

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