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How do I permanently kill native milkweed?

I planted native milkweed three years ago for the Monarchs. The Monarchs all, as in every single one, had OE so, last fall after two years of growth I decided to dig up the milkweed. This spring I have dug up shoots no less than four times, removing as much of the root as I could follow in the soil. I can tell the next time it pops up will be too near my perennials to dig up. What can I spray on the milkweed to kill it? Regular Round-Up sprayed twice on consecutive days did not phase it the least.

I truly understand the phrase "noxious weed" which is also used to describe native milkweed. I hope this post serves as a warning to other uninformed people who are considering planting it. In my opinion, native milkweed should never be recommended without a dire warning in the same sentence.

I also grow butterflyweed, tropical milkweed and swamp milkweed that appear to be ok.

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