If your cukes do indeed have bacterial wilt they are dead, nothing will save them.

The Safer 3 in 1 is simply a neem spray and I am a huge fan of neem oil. I have not used the product you have, but I have used Safer Bio-Neem and regular pressed neem oil.

I tend to use neem oil preventatively on plants I know from previous years are prone to particular pests or leaf diseases. Very happy with it although it isn't 100% (nothing is).

How long you have to wait to see results depends on the product and the problem. Neem doesn't kill on contact, it kills over the course of days only after the insect eats sprayed plant material. It does stop feeding quickly though and prevents the bugs from reproducing.

The insecticidal soap is a contact killer and must be applied directly to the insect to work. It is great on soft bodied pests like aphids and whiteflies, marginal on caterpillars and may or may not kill beetles depending on how much gets on them. As soon as it dries, it will no longer control anything.

The pyrthrins are a contact toxin as is the rotenone. Read the label very carefully on all products, but particularly these two. They are serious pesticides and organic doesn't make them safe. Anything that comes in contact with either will die anywhere from seconds to minutes later. I would keep these two in your back pocket as a last resort if you can't get things under control with neem oil.

These two will kill all insects, not just pests so it is the 'nuclear' approach to pest management and frequent use of either tends to lead to an increased dependence on them as the predator bugs are wiped out and the pest bugs reproduce and repopulate much faster.

When the season is over remove all plant debris from the garden, particularly the stuff you know was diseased or bothered by pests. This cleanup step can prevent overwintering of *some* insects/disease although plenty will migrate in next year anyway.

If you can bring yourself to do it I would also recomend that other than the Neem oil just take a step back and observe what goes on in your garden the rest of the year.

Much of the time pest problems take care of themselves or are very short lived or do not do enough damage to be worth controlling.

There are exceptions such as disease spreading cucumber beetles on cucumbers (most other cucurbits are more resistant to wilt), but really you should find the need to do insect control fairly rare in most cases.

Thanks! Is there any way to tell if it is bacterial wilt?

cut off a wilted branch near the stem and squeeze the end. If a milky 'ooze' comes out you have bacterial wilt.

If your cukes have wilt they will decline steadily day by day and be completely dead within 2 weeks, often less.