We have one and wouldn't have it any other way.
This whole ick factor with the handle is ridiculous. Not sure what you are getting on your hands and if there were something on your hands you go to the sink after using the toilet and wash your hands. The only time you are touching the handle of that door is to leave after using the toilet and again you go to the sink to wash your hands so where are all these germs going other than the door handle? I guarantee the other door handles in your house are just as germy.
I have had toilet rooms in every master bathroom in all my houses. Never got sick from a dirty bathroom door handle.
The whole gas chamber is ridiculous thing to say as well. There is a vent fan in the toilet closet to deal with smells. I guess people would rather stink up the entire bathroom rather than a smaller toilet room where you can close the door to keep any smell contained and let the fan vent it.
If you don't want a toilet closet then don't have one but the reasoning people come up with for not having makes no sense.
Q