More pictures will be helpful.

Maybe a tall plant on the left side and some colorful art on the right? The look can range from very simple to very busy.

It's a lovely room with lots of potential. I would paint the TV wall in a calm, deep accent color. Like a subtle taupe gray to compliment the fireplace and the couch. Add a long console table under the tv in a warm wood tone. (Tall enough to hide wires and give a focal point and wide enough to add thin accent lamps or tall candle sticks or vases.) Move the plant to the left corner. Center the wine rack on its current wall on the section away from the cut out. Find a unique mirror to hang over the wine rack to add depth to the room. (Like a window would.) Find matching pieces of large artwork and hang on either side of the TV - spaced just a few inches past the corners of the large console.. You can place the lamp to the left of the wine rack for added light in that space. A warm wood tone mantle will also add warmth to your room. Good luck! I hope you show us what you did when you're done!

The TV looks high. Do you like watching it so high? I don’t understand the end table with lamp. Is there a chair next to it? Can we see the rest of the room? There may be a better spot for the TV. With only this picture to go by, I would start by closing the drawer in the hutch and removing the garland. The figures on the mantle are too small. They may be happier in the hutch. Add a low, but heavy thing to the mantle, like a big sea shell or an animal sculpture . What types of things do you collect? What colors do you like? More info will bring better suggestions.