Not sure on what might go on in your bedroom, but are you really concerned about durability of leather on a headboard? Leather gets a patina that is attractive. There is more wear and tear on a sofa than on a headboard. Any leather or fabric headboard can be sprayed with a standard waterproofing you use on shoes and boots, to protect it from any water stains. If you're concerned about hair products staining on leather or fabric, I'd recommend Crypton Fabric Protection being sold by the furniture stores. Success for the room is dependent on where your windows and doors are located & how you lay out the room. I have attached a somewhat standard layout using the Universal bedroom set dimensions you noted with the King Size bed, dresser and 2 nightstands. If you use a King size bed, you'll want the larger sized nightstands so the proportions are appropriate to the bed. I'm not a fan of putting the dresser across from the bed, but I don't know where your windows are located. I don't recommend the use of mirrors over dressers. It's passe', and it's only promoted by the furniture manufacturers. People get made up in their bathrooms and closets. I recommend a full length mirror be installed somewhere for your use in your bed/bath suite. If you want a flatscreen in the bedroom, it could simply be mounted on the wall alone or with a small shelf beneath it. The bedroom pic in my first posting only had the bed, 2 nightstands and a chest for the husbands clothes and that room was pretty close in size to yours, but only 2 windows to deal with.

An economical primer may lead to paint failure or poor sheen appearance in the topcoat. You want to lay down a quality acrylic primer to ensure a beautiful finish. A quality primer will have very good enamel holdout which maintains the sheen of the topcoat. Don't settle for anything less. I recommend BM Fresh Start Acrylic or Zinsser Bulls Eye 1 2 3 acrylic. Michael

What a great resource hestia! If I lived in that area of the country I'd definitely be checking it out.

Will it be painted? Even if you think knot holes won't matter if the boards will be painted, consider bleed thru issues - it will happen unless you get boards with as few as possible knot holes and/or prime with a shellac based primer. I speak from experience. :( at least when it came to putting it up in the kitchen I had already experienced the nightmare of orange spots all over my nicely painted white trim and baseboard in the bedroom.