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Iris GW

Brazil is likely to sign a contract this week to produce a trial vaccine developed by Oxford University to guard against the novel coronavirus, the country's interim health minister Eduardo Pazuello said on Tuesday.

Human clinical trials in Brazil for the potential vaccine started this weekend with 3,000 people in Sao Paulo and Rio de Janeiro.

Interim health minister Eduardo Pazuello said in a hearing with lawmakers that a deal could be signed tomorrow and that other partnerships with vaccines developers could also be forged soon.

Good news, I hope.

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abzzybee(9/10 S. Florida)

I'm leaning in the direction that there will not be a successful vaccine for covid-19 in less than 5 years if ever. Too many trials so far have fizzled or even failed spectacularly with some of the participants getting extremely ill. Another reason is that so far it appears that there is no lasting immunity conferred when someone did have covid-19 and recovered from it. What would a vaccine do differently in terms of immunity?

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how2girl

Brazil registered an additional 1,374 deaths from the virus on Tuesday and 39,436 new cases, pushing the coronavirus death toll to 52,000. More than 1.1 million have been infected.

With the dire situation in Brazil I wonder if people are desperately lining up to be vaccine guinea pigs.

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lurker111

Oxford University...Bill Gates.

AstraZeneca - Bill Gates.

Uh-huh!

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terezosa / terriks

^^^🙄🙄🙄

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lurker111

Follow the money.

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how2girl

Bill gates has become the voodoo doll of Corona virus conspiracy theorists.

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lurker111

And then it all becomes obvious. You should have watched the videos I posted with the Chinese doctors. The cat is out of the bag.

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zmith

It’s obvious alright.

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linaria_gw(zone 7 (about))

There are regular podcasts or interviews with a Germn expert on Coronavirus, Christian Drosten. He estimates that a year to 18months till there is a tested new vaccine in usefull quantities should be realistic. And he is always very cautious or upfront if there are problems or something. An important factor, according to him, is that there is a tested vaccine type that could be modified -which saves time.


Apart from that he describend several methods how a new vaccine could work in general, but the medical technicalaties went over my head.


In a very small nutshell


there are ways to teach an immune system to produce certain antibodies (to be prepared tor the infection)

or use antibodies to fight an infection immediately


(and probably 2-3 others which I forgot)


and then there could be medicines to deal with the worst effects of covid 19, but the whole medical community is still learning details, he cautionend.


nothing detailed yet, but definetely better than in 5 years time...

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HamiltonGardener

A new study from researchers at La Jolla Institute for Immunology (LJI) and Erasmus University Medical Center (Erasmus MC) shows that even the sickest COVID-19 patients produce T cells that help fight the virus.

The study offers further evidence that a COVID-19 vaccine will need to elicit T cells to work alongside antibodies.The research, published June 26, 2020 in Science Immunology, also reveals that both Dutch and American patients have similar responses to the virus.

"This is key to understanding how the immune response fights the virus," says LJI Professor Alessandro Sette, Dr. Biol. Sci., who co-led the study with Erasmus MC Virologist Rory de Vries, Ph.D. "You want vaccine approaches to be grounded in observations from rather diverse settings to ensure that the results are generally applicable."

For the study, the researchers followed ten COVID-19 patients with the most severe disease symptoms. All ten were admitted to the ICU at Erasmus University Medical Center, in the Netherlands, and put on ventilators as part of their care.

Two of the patients eventually died of the disease. An in-depth look at their immune system responses showed that all ten patients produced T cells that targeted the SARS-CoV-2 virus. These T cells worked alongside antibodies to try to clear the virus and stop the infection.

"Activating these cells appears to be at least as important as the production of antibodies," says Erasmus MC Virologist Rory de Vries, Ph.D., who co-led the study with Sette.

These findings are in line with a recent Cell study from Sette, LJI Professor Shane Crotty, Ph.D., and LJI colleagues that showed a robust T cell response in individuals with moderate cases of COVID-19. In both studies, the T cells in these patients prominently targeted the "spike" protein on SARS-CoV-2.

The virus uses the spike protein to enter host cells, and many vaccine efforts around the world are aimed at getting the immune system to recognize and attack this protein. The new study offers further evidence that the spike protein is a promising target and confirms that the immune system can also mount strong responses to other targets on the virus.

https://www.news-medical.net/news/20200630/Study-Even-the-sickest-COVID-19-patients-produce-T-cells-that-help-fight-the-virus.aspx

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Mimou-GW

The Bill and Melinda Gates Foundation has contributed $750 million towards the manufacturing and distribution a potential COVID-19 vaccine developed by Oxford University.

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patriciae_gw(07)

Well there you are. They must be some sort of nexus of monstrosity. Not of course people who want lives saves.

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elvis

Mimou-GW

The Bill and Melinda Gates Foundation has contributed $750 million towards the manufacturing and distribution a potential COVID-19 vaccine developed by Oxford University.

Excellent. They'll never miss it.

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HamiltonGardener

More hopeful news



Marcus Buggert, assistant professor at the Centre for Infectious Medicine, Karolinska Institutet, and one of the paper’s main authors, said: “T-cells are a type of white blood cells that are specialised in recognising virus-infected cells, and are an essential part of the immune system.

“Advanced analyses have now enabled us to map in detail the T-cell response during and after a COVID-19 infection. Our results indicate that roughly twice as many people have developed T-cell immunity compared with those who we can detect antibodies in.”



.........................


“Moreover, roughly 30 per cent of the blood donors who had given blood in May 2020 had COVID-19-specific T-cells, a figure that’s much higher than previous antibody tests have shown.”



https://www.sciencefocus.com/news/covid-19-public-immunity-significantly-higher-than-tests-suggest/

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