Avoid coadministration of hydroxychloroquine and azithromycin

HU-5213567

Azithromycin: (Major) Avoid coadministration of hydroxychloroquine and azithromycin due the risk of additive QT prolongation. If use together is necessary, obtain an ECG at baseline to assess initial QT interval and determine frequency of subsequent ECG monitoring, avoid any non-essential QT prolonging drugs, and correct electrolyte imbalances. Hydroxychloroquine prolongs the QT interval. QT prolongation and torsade de pointe (TdP) have been spontaneously reported during azithromycin postmarketing surveillance.

https://m.pdr.net/Mobile/Pages/drug-summary/Plaquenil-hydroxychloroquine-sulfate-1911

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Blanche Dubois

I had to look up QT prolongation For anyone else who didn't know


QT prolongation
is a measure of delayed ventricular repolarisation, which means the heart muscle takes longer than normal to recharge between beats


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socks(10a)

What is PDR.net.? While I don’t doubt this is true but would rather see it from the AMA or a physicians group.

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Blanche Dubois

It used to be called Physicians Desk Reference.. remember that? It was the go to book for drugs/interactions/etc. https://onlinelibrary.wiley.com/doi/full/10.1111/ijcp.12992

https://en.wikipedia.org/wiki/Physicians%27_Desk_Reference

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HU-5213567

PDR is the most commonly used drug reference.

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Gooster(9)

It's been an existing interaction warning in place for some time. That's why trials are proceeding with care, due to the known issues.

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socks(10a)

Oh, of course. I didn’t make the connection. I work(ed) in a used bookstore, and we got those chunky volumes in often.

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