Avoid coadministration of hydroxychloroquine and azithromycin
Azithromycin: (Major) Avoid coadministration of hydroxychloroquine and azithromycin due the risk of additive QT prolongation. If use together is necessary, obtain an ECG at baseline to assess initial QT interval and determine frequency of subsequent ECG monitoring, avoid any non-essential QT prolonging drugs, and correct electrolyte imbalances. Hydroxychloroquine prolongs the QT interval. QT prolongation and torsade de pointe (TdP) have been spontaneously reported during azithromycin postmarketing surveillance.