More progress, CovidRx UBC and international team!

tryingtounderstand

A trial drug that could aid in the fight against COVID-19 has been found.

The discovery was made by an international team of researchers, led by University of British Columbia researcher Dr. Josef Penninger.

Dr. Penninger is a research chair in functional genetics at UBC in Vancouver.

The findings, published Thursday in Cell, outline a trial drug which effectively blocks the cellular door SARS-CoV-2, the virus that causes COVID-19, uses to infect its hosts.

“We are hopeful our results have implications for the development of a novel drug for the treatment of this unprecedented outbreak,” says Dr. Penninger.

“This work stems from an amazing collaboration among academic researchers and companies, including STEMCELL Technologies in Vancouver, Nuria Montserrat in Spain, Drs. Haibo Zhang and Art Slutsky from Toronto and Ali Mirazimi’s infectious biology team in Sweden, who have been working tirelessly day and night for weeks to better understand the pathology of this disease and to provide breakthrough therapeutic options.”

While the COVID-19 outbreak continues to spread around the globe, the absence of a clinically proven antiviral therapy specifically targeting the critical SARS-CoV-2 receptor ACE2 on a molecular level has meant there is no vaccine for health care providers struggling to treat severe cases of COVID-19.

“Our new study provides direct evidence that a drug — called APN01 (human recombinant soluble angiotensin-converting enzyme 2 – hrsACE2) — soon to be tested in clinical trials by the European biotech company Apeiron Biologics, is useful as an antiviral therapy for COVID-19,” says Dr. Slutsky.

“The virus causing COVID-19 is a close sibling to the first SARS virus,” adds Dr. Penninger.

“Our previous work has helped to rapidly identify ACE2 as the entry gate for SARS-CoV-2, which explains a lot about the disease. Now we know that a soluble form of ACE2 could be indeed a very rational therapy that specifically targets the gate the virus must take to infect us.

"There is hope for this horrible outbreak.”

https://www.castanet.net/news/BC/296345/UBC-at-forefront-of-possible-COVID-19-treatment#296345

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Comments (27)
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elvis

Thank you for sharing this, ttu. We'll take every bit of promising news!

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lovemycorgi

Yes, thank you so much for sharing! It's nice to possibly see a light at the end of this dark tunnel. I am in SE Michigan and we've unfortunately become quite a hot spot for covid infections.

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Nana H

So many great things happening. So many smart heroes. Hats off to them all.......

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maddiemo

This is such good news. Thanks for sharing. I’m sure every day brings a vaccine closer.

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Ziemia(6a)

So, why isn't Trump talking about this one?

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tryingtounderstand

^^^^perhaps, cause it’s not made in the USA !

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Olychick

And apparently he blocked sharing PPE and other equipment with Canada. Let's hope that doesn't bite us all in the a$$. But they are more generous and empathetic than him. (Isn't everyone, but his supporters)?

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roxsol

“And apparently he blocked sharing PPE and other equipment with Canada.“

https://www.google.ca/amp/s/beta.ctvnews.ca/national/2020/4/6/1_4885409.html

Minnesota-based 3M, which has been at the centre of a clash with President Donald Trump and his administration over the company's reluctance to abide by orders to prioritize American demand for the masks, confirmed plans to continue to fill orders in Canada and Latin America.“


"The plan will also enable 3M to continue sending U.S.-produced respirators to Canada and Latin America, where 3M is the primary source of supply."


A deal was made, Canada will still get masks from 3M.

(It was just more unnecessary chaos created by President Trump, similar to his statement about placing the army along the Canada-USA border)

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heri_cles

$99 for .02 mg of ACE2 (for research use only)

What is the timeline for testing drugs like this?

We can't wait a year and a half.


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tryingtounderstand

@Okychick, Trudeau has said, he is is not interested in any retaliatory measures. So no worries, we would share anything we have while also taking care of our own. Kind of like multi tasking.

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tryingtounderstand
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queenmargo

So, why isn't Trump talking about this one?

Well, if he did the left would find outrage, so why not just be happy instead of dredging up a way to insult Trump. These comments are so disingenuous.

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queenmargo

Why isn't Biden talking about anything? He is just nay-saying in his basement.

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Ziemia(6a)

He'd have to use the DPA to change the recipient of those masks - he just won't do it.

Minnesota-based 3M, which has been at the centre of a clash with President Donald Trump and his administration over the company's reluctance to abide by orders to prioritize American demand for the masks, confirmed plans to continue to fill orders in Canada and Latin America.“

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tryingtounderstand

Canada begins vaccine trials! More promise on the horizon, as vaccine research continues. https://www.ctvnews.ca/health/coronavirus/health-canada-approves-first-clinical-trial-for-potential-covid-19-vaccine-1.4942507

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Nana H

Canada was instrumental in the development of a vaccine for Ebola hopefully this one is a winner too!

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tryingtounderstand

Fingers crossed Nana! Happy long weekend, hopefully the weather will be good. We are on the loooong journey west. Lots of sunshine across the prairies.

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Izzy Mn(4)

Trump shouldn't be talking about the possible treatment in OP. It should be Dr Fauci and Dr. Brix who would be the sane choice to talk on this.

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elvis

Thanks much for the update, ttu! More good news, we'll take it.

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Nana H

TTU, lovely May weekend so far, a bit "coolish" but sunny and bright. Got the boat and wave runner in so that speaks summer. Alas though no fireworks. Travel safe.

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lurker111



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maifleur03

A little premature video since it is only supposition that the virus originated in Wuhan but I doubt if anyone will change their minds when it is proven where it came from and how long it has been around.

I keep wondering at the drums beating that it was China, China, and not our government that allowed it to become out of hand in the US. Could it be it is because some actually want a shooting war with China or another country?

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lurker111

Yeah, I'm still watching it. You might want to watch it before commenting.

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maifleur03

Like I posted, keep beating on those drums. Sadly with the current administration you may get your wish.

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lurker111

Such rhetoric.

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elvis

Nana H

...Got the boat and wave runner in so that speaks summer. Alas though no fireworks. Travel safe.

I do wish you would re-think that PWC.

Two-cycle gasoline engines on personal watercraft are known to discharge as much as one-third of their unburned fuel into the water. In a single hour of run time, a 2000-model PWC will dump about 4 gallons (15 liters) of unburned oil and gas into the water. However, newer models with direct fuel injection are more efficient. They dump less fuel into the water, and that's a step in the right direction.

Other PWC environmental problems include extreme noise pollution from engines, as well as pollution from the gasoline additive MTBE. When the craft leak fuel into the water, MTBE tends to collect in shallow, shoreline areas, killing plankton and other tiny sea life that is the basis for many water ecosystems.


So are PWC environmentally doomed? It's hard to say. Manufacturers have made changes to the engines that make the craft less damaging to the environment. That, along with changes to levels of engine noise, could eventually get them back into some recreation areas from which they've been banned. But wildlife and PWC may never go hand-in-hand, and parks concerned for their sea life may never give the craft another chance.

https://science.howstuffworks.com/environmental/green-science/watercraft-destroy-planet2.htm

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Nana H

Elvis, still using your motorcycles?

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