Here are some pieces I'm looking at...

Take your house floor plan and map it out on graph paper with a 1 square = 1 foot scale (ie a real to scale model or your space; and not just the room itself... where the door is; where the plumbing (bathrooms) are, etc). Then, scan it and post it. Then, we can better offer feedback.

To answer your direct questions: Put the darker color behind the bed headboard and then decide if you want one accent wall (usually a lot of contrast) or if you want to have two walls each color. The Santorini Blue is not baby blue, but I would put a color swatch in your room to see how it looks in different light if you decide to go in that direction. Glass Slipper is more ice blue than baby blue. I LOVE the Santorini blue, but thought it was too dark to have on all four walls. Your bedding is very neutral and very pretty. When I look at it I think "irredesence" or opal. Everyone does this differently, but I tend to decide what I want a room to FEEL like and then go from there. For our bedroom I thought "sleeping in the clouds". Hence, I have blues, whites, creams and beige. For our bathroom I wanted "beach spa". I also suggest you look through the bathroom pictures on the bathroom forum. I found several inspirational rooms that worked with the tile and cabinets we had. I think one of the reasons you are struggling is that you are working with "what matches" instead of what look do I love. Love something, make it work in your room. Having said that, I think your tile would work well with blues, tans or many of the greiges. Whatever you decide, you are likely going to need an accent color since your bedding has wonderful texture, but only one color. Again, look at the bathroom forums pictures and here in gallary under "bathrooms". Which rooms catch your breadth or you say to yourself, "I want that feeling". Good luck!

Here is an idea similar to plan D. Moving the doorway to the bathroom and enlarging the vestibule gives you a couple more options and does not seem so constricted. You can have a door between the vestibule and bedroom to allow use of the office, closet and bathroom at night with out light getting into the bedroom. You could eliminate the door into the bathroom if you keep a door on the toilet area. Or you could keep the door on the bathroom and eliminate the door on the toilet area. Or you could keep all the doors.