I had the same thoughts before reading everyone else's posts...The 3 x 6 is more 'standard' and traditional, while the 4x8 would be a little more unique and bring a modern or industrial twist or zing to your kitchen...which I can like with traditional elements. Depends on what you want it to do. And Plllog does have a point about smaller tiles fitting in around things better, but I wouldn't necessarily let that decide it for me. Will one fit in the spaces using whole tiles, while the other will require cutting all the way along? (Remember to figure in grout lines) Even if I liked one better, if the other fit in whole, THAT could sway me to change my mind.

Regarding the grout, if you're doing a grout color that is in line with the color(s) in the tile it shouldn't look too busy in any size. I saw a stunning photo the other day of a pretty busy granite, light splash tiles and super dark grout so it doesn't all have to be super muted to blend. As for what the lady said, if you love the 6x6 more than the others, do it. I have short splash on both walls of my kitchen due to cabs and a window so 6x6 would never work but I like the looks of them and didn't realize it was a trend, but what do I know? It's not like squares are some fancy new, trendy shape. ;) Maybe someone else will have better advice on that. Here is a link below. Here is a link that might be useful: Mostly 6x6 backsplash tiles

Choosing a backsplash has been torture! I am trying to flow with the Mascarello granite & not compete with it. The colors are impossible. I think the Crema marble is elegant, but is it too light, or too plain or too hard to keep clean? Any advice would be appreciated? I change my mind every 5 minutes, day & night! Here is a link that might be useful: Backsplash Choices

I think you should go for it. I think that a big hangup is cost. With tile it is 1. costly, and 2. A big ordeal to replace. But, when talking about using a paint color that is a little outside the box, people say, "oh, it's only paint, so pick a color you love and change it down the road if you want". However, let's be real people....paint is not cheap. Not if you buy expensive paint, equipment, or hire someone to do it for you. And just because it is expensive, it doesn't mean you probably won't change your mind and repaint at some point. I think most of us with a tile backsplash would be less likely to change it out because we remember the cost, but do we remember how much that paint job cost 8 years ago? Probably not, therefore we would repaint but not retile. So, if you love that blue tile and live with it for many years and for some reason you hate it in 10 or so years, rip it down and replace it. And by the way, orange goes very nicely with blue. :)