If it were me, I'd copy all the files onto the USB drive. (You're just copying, not burning)

On the target machine, I'd open up the USB drive and look for "setup", "setup.exe", "install", "install.exe" or similar. If I couldn't see what I needed to run, I might look in "autorun.inf", if it exists.

Unless it's a copy protected game or something like that, you should have no problem.

Thanks. Was going to give it a try, just wanted an opinion as to whether I'd be wasting my time. Not copy protected, but has activation key, which I have.

Won't hurt to try! Many Devices today aren't coming with CD/DVD Drives. Tablets for instance. My new Acer Iconia W4-820 Tablet doesn't have a CD/DVD, but an External can be hooked up with the USB Adaptor. My New Acer Aspire Ultrathin V5 573p-6896 Laptop doesn't have a CD/DVD Drive either (too thin). Again, I can hook up and External CD/DVD Drive. I do have an External Lite-On CD/DVD Burner I can use most of the time, so I've never really had the need to copy to a USB Flash Drive.

Usually any program on a CD/DVD has been updated and can be downloaded from the programs website.

Yeah, but I'd have to pay for the upgraded version. The one I have suits my purposes just fine.

I agree aufin, I don't like paying to upgrade unless it's something I want to do! Many programs I'm satisfied with and don't want to upgrade! Lots of the time you end up losing features you really like because a software developer decided it was a worthless feature! I do like being able to Try a New Version to see if it's worth my time and money, just don't like dishing the $$$ out unless I'm sure!