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marshallz10

Further indictment of Roundup in the environment

marshallz10
18 years ago

The ongoing defense of Roundup and other glyphosate-containing herbicide mixes insists that the formulations are safe and short-lived in the environment. Well, a batch of new research studies, mostly out of Europe, call these defenses into question. Here is a recent report.

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Environmental Health Perspectives Volume 113, Number 6, June 2005

Differential Effects of Glyphosate and Roundup on Human Placental Cells

and Aromatase

Sophie Richard, Safa Moslemi, Herbert Sipahutar, Nora Benachour, and

Gilles-Eric Seralini

Laboratoire de Biochimie et Biologie Moleculaire, USC-INCRA, Université

de Caen, Caen, France

Abstract

Roundup is a glyphosate-based herbicide used worldwide, including on

most genetically modified plants that have been designed to tolerate it.

Its residues may thus enter the food chain, and glyphosate is found as a

contaminant in rivers. Some agricultural workers using glyphosate have

pregnancy problems, but its mechanism of action in mammals is

questioned. Here we show that glyphosate is toxic to human placental

JEG3 cells within 18 hr with concentrations lower than those found with

agricultural use, and this effect increases with concentration and time

or in the presence of Roundup adjuvants. Surprisingly, Roundup is always

more toxic than its active ingredient. We tested the effects of

glyphosate and Roundup at lower nontoxic concentrations on aromatase,

the enzyme responsible for estrogen synthesis. The glyphosate-based

herbicide disrupts aromatase activity and mRNA levels and interacts with

the active site of the purified enzyme, but the effects of glyphosate

are facilitated by the Roundup formulation in microsomes or in cell

culture. We conclude that endocrine and toxic effects of Roundup, not

just glyphosate, can be observed in mammals. We suggest that the

presence of Roundup adjuvants enhances glyphosate bioavailability and/or

bioaccumulation. Key words: adjuvants, aromatase, endocrine disruption,

glyphosate, herbicide, human JEG3 cells, placenta, reductase, Roundup,

xenobiotic. Environ Health Perspect 113:716-720 (2005).

doi:10.1289/ehp.7728 available via http://dx.doi.org/ [Online 25

February 2005]

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